中国药科大学

柳红（兼职导师），女，现任中国科学院上海药物研究所研究员、课题组长、博士生导师。国家杰出青年、中国科学院百人计划、第八届中国青年女科学家获得者。1999年毕业于中国药科大学药物化学系，获得理学博士学位；1999年至2001年期间在中国科学院上海药物研究所从事博士后研究，后留所工作。分别于2002年、2005年在美国The University of Texas Medical Branchat Galveston进行访问学习和研究工作。主要从事药物化学、化学生物学和药物设计研究。近年来紧扣“新药先导化合物的发现和优化”这条主线，构建了“有机合成新方法促进药物发现”新药研究技术体系，主要针对感染性疾病、肿瘤、代谢疾病以及老年性痴呆等重大疾病进行新药创制研究，发现了一批具有深入研究价值的候选化合物，有3个化合物正在进行全面的临床前研究。围绕药物分子的优势骨架，发展了一系列具有原始创新、高效的合成方法体系，构建了含有6000个分子的多样性“优势骨架杂环库”。在Chemical Reviews、Angewandte Chemie International Edition、Journal of Medicinal Chemistry、Chemistry & Biology、Organic Letters、Chemical Communications和Green Chemistry等国际学术期刊发表论文260篇，申请专利49项，获得发明专利证书13项，参与9本专著的编写。

作为课题负责人承担863、973、国家自然科学基金重大研究计划重点支持项目、国家杰出青年基金项目、国家科技重大专项、欧盟F7框架SILVER项目、科技部国际合作项目、上海市学术带头人计划等项目。获得第八届中国青年女科学家奖、“国家自然科学”二等奖、中国化学会“青年化学奖”、上海市“科技进步一等奖”等多项奖励，获得第六届全国优秀科技工作者、国家杰出青年、中科院百人计划、全国“三八红旗手”、上海市优秀“学术带头人”等荣誉称号。担任中国药学会药物化学专业委员会委员、上海药学会药物化学专业委员会委员、上海市妇联妇代会执委委员等，任药学学报、中国药物化学杂志编委会成员；任国际刊物ACS Combinatorial Science,Organic Chemistry:Current Research,Current Microwave Chemistry,Current Green  Chemistry编委等职务。

联系方式：电话：021-50807042,邮箱：hliu@simm.ac.cn

代表性文章：

1.Jiang Wang, José Luis Aceña, Santos Fustero, Carlos del Pozo, María Sánchez-Roselló, Vadim A. Soloshonok,* Alexander E. Sorochinsky, Hong Liu*. Fluorine in Pharmaceutical Industry; Fluorinated Drugs Introduced to the Market in the Last Decade. Chemical Reviews. 2014, 114, 2432-2506. (IF=45.661)

2.Yong Nian, Jiang Wang, Shengbin Zhou, Shuni Wang, Hiroki Moriwaki, Aki Kawashima, Vadim A. Soloshonok* and Hong Liu*, Advanced Approach for Purely Chemical Dynamic Kinetic Resolution of Tailor-made α-amino Acids, Including Substrates Containing Tertiary and Unprotected Multifunctional Groups. Angewandte Chemie International Edition. 2015, in press. (IF=11.336)

3.Shengbin Zhou, Jiang Wang, Xia Chen, José Luis Aceña, Vadim A. Soloshonok,* and Hong Liu*. Chemical Kinetic Resolution of Unprotected b-Substituted-b-Amino Acids Using Recyclable Chiral Ligands. Angewandte Chemie International Edition. 2014, 53, 7883-7886. (IF=11.336)

4.Ryosuke Takeda, Akie Kawamura, Aki Kawashima, Tatsunori Sato, Hiroki Moriwaki,* Kunisuke Izawa, Kenichi Akaji, Shuni Wang, Hong Liu,* Jos  Luis AceÇa, and Vadim A. Soloshonok*. Chemical Dynamic Kinetic Resolution and S/R Interconversion of Unprotected a-Amino Acids. Angewandte Chemie International Edition. 2014,53, 12214-12217. (IF=11.336)

5.Tingting Li, Shengbin Zhou, Jiang Wang, José Luis Aceña, Vadim A. Soloshonok,* and Hong Liu*. Asymmetric synthesis of α-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges. ChemComm. 2015, 51, 1624--1626. (IF=6.718)

6.Wei Zhu, Dengyou Zhang, Nan Yang and Hong Liu*. Copper-mediated C-H(sp2)/C-H(sp3) coupling of benzoic acid derivatives with ethyl cyanoacetate: an expedient route to isoquinolinone scaffold. ChemComm. 2014, 50, 10634 - 10636. (IF=6.718)

7.Fei Zhao, Dengyou Zhang, Yong Nian, Lei Zhang, Wei Yang, and Hong Liu*. Palladium-catalyzed Difunctionalization of Alkynes via C-N and S-N Cleavages: a Versatile Approach to Highly Functional Indoles. Organic Letters. 2014, 16, 5124−5127 .(IF=6.324)

8.Hao Cai, Yu Zhou, Dong Zhang, Jinyi Xu*, and Hong Liu*. A Mannich/Cyclization Cascade Process for the Asymmetric Synthesis of Spirocyclic Thioimida-zolidinexoindoles. ChemComm. 2014,50,14771-14774. (IF=6.718)

9.Manuel Jörres, Xia Chen, José Luis Aceña, Carina Merkens, Carsten Bolm,* Hong Liu,* and Vadim A. Soloshonok*. Asymmetric Synthesis of a-Amino Acids under Operationally Convenient Conditions. Adv. Synth. Catal. 2014, 356, 2203-2208. (IF=5.542)

10.Enguang Feng, Woo-Jin Shin, Xuelian Zhu, Jian Li,  Deju Ye,  Jiang Wang, Jian-Ping Zuo,  Kyoung Tai No,  Mingyue Zheng,  Weiliang Zhu, * Wei Tang, * Baik-Lin Seong,*  Hualiang Jiang,  and Hong Liu* Structure-Based Design, Synthesis of C-1 and C-4 modified analogs of zanamivir as neuraminidase inhibitors. Journal of Medicinal Chemistry 2013, 56, 671-684. (IF=5.614)

11.Jiahui Wu, Dengyou Zhang, Lei Chen, Jianneng Li, Jianling Wang, Chengqing Ning,Niefang Yu, Fei Zhao,Dongying Chen,Xiaoyan Chen,Kaixian Chen, Hualiang Jiang, Hong Liu*,and Dongxiang Liu*, Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate Journal of Medicinal Chemistry 2013, 56,761-780. (IF=5.614)

12.Lei Zhang, Fei Zhao, Mingyue Zheng, Yun Zhai and Hong Liu* Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-adducts under microwave heating ChemComm 2013,49,2894-2896. (IF=6.378)

13.Daizong Lin, Jiang Wang, Xu Zhang, Shengbin Zhou, Jie Lian, Hualiang Jiang and Hong Liu* Highly diastereoselective synthesis of 3-indolylglycines ChemComm  2013,49,2575-2577. (IF=6.378)

14.Shengtao Xu, Yu Zhou, Jinyi Xu*, Hualiang Jiang, and Hong Liu* Gold-catalyzed Michael Addition/Intramolecular Annulation Cascade: an Effective Pathway for the Chemoselective- and Regioselective Synthesis of Tetracyclic Indole Derivatives in Water Green Chemistry. 2013,15,718-726. (IF=6.828)

15.Jinfang Wang, Yu Zhou,* Lei Zhang, Zeng Li, Xianjie Chen and Hong Liu*. Asymmetric Michael Addition of N-tert-Butanesulfinyl Imidates: an Efficient Strategy for the Synthesis of (R)-3-Substituted Indanone Derivertives. Organic Letters. 2013,15,1508-1511. (IF=6.142)

16.Xianjie Chen , Hui Chen, Xun Ji, Hualiang Jiang, Zhu-Jun Yao, and Hong Liu*. Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro [pyrrolidin-3, 2′-oxindole] Derivatives Organic Letters. 2013,15,1846-1849. (IF=6.142)

17.Dengyou Zhang, Haifeng Sun, Lei Zhang, Yu Zhou, Chunpu Li, Hualiang Jiang, Kaixian Chen, and Hong Liu.* An Expedient Pd/DBU Mediated Cyanation of Aryl/Heteroaryl Bromides With K4[Fe(CN)6]. ChemComm 2012, 48, 2909–2911. (IF=6.378)

18.Qian Ba, Miao Hao, He Huang, Junmei Hou, Shichao Ge, Zhuzhen Zhang, Jun Yin, Ruiai Chu, Liang Hua Jiang, Fudi Wang, Kaixian Chen, Hong Liu*, and Hui Wang* .Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin. Cancer Res. 2011, 17, 7625-7633. (IF=7.837)