中国药科大学

洪浩，博士，教授，博士生导师，教育部创新团队成员，江苏省首席科技传播专家，中国药理学会神经精神药理专业委员会委员，中国药理学会抗衰老与老年痴呆专业委员会委员，江苏省药理学会常务理事及教学专业委员会秘书长，“神经药理学报”编委，“Metabolic Brain Disease”（USA）编委。洪浩教授于1989年6月毕业于中国药科大学，2001年6月获安徽中医学院医学硕士学位，2004年6月获中国药科大学理学博士学位，2006年10月从KinkiUniversity（Japan）留学回国。近年来，承担药理学、当代药理学及表观遗传学等课程的教学工作；主持和参加国家自然科学基金面上项目、“十一五”和“十二五”国家“新药创制”科技重大专项等多项国家及省部级科研项目；在国际知名杂志如Neurobiology of Aging，Int J Neuropsychopharmacol，Neuropharmacology，British J Pharmacol，J Neurochem等发表研究论文30余篇；申请国内发明专利3项；参编著作1部。

研究方向：神经药理。采用分子遗传学、细胞分子生物学及动物行为学等实验方法探寻介导阿尔茨海默病（AD）及相关疾病（如抑郁症和糖尿病）发生发展的关键分子，确证其作为药物调控的分子靶标，并以此为基础发掘活性物质、开发防治药物。当前正在研究的课题有国家自然科学基金面上项目2项、“十二五”国家重大新药创制项目1项以及江苏省自然科学基金项目1项。

联系方式：honghao@cpu.edu.cn;haohongchina@hotmail.com,025-86185227，83271157，江宁校区综合研发楼551室。

近期已发表的代表性论文:

1. Miao-Jin Ji, Xu-Ben Yu, Zhen-Lin Mei, Yun-Qi An, Su-Su Tang, Mei Hu, Yan Long, Ming-Xing Miao, Qing-Hua Hu, Hong-Bin Sun, Ling-Yi Kong, and Hao Hong*. Hippocampal PPARδ overexpression or activation represses stress-induced depressive behaviors and enhances neurogenesis. Int J Neuropsychopharmacol. In Press.
2. Fang Chen, Rong Rong Dong, Kai Long Zhong, Arijit Ghosh, Su Su Tang, Yan Long, Mei Hu, Ming Xing Miao, Jian Min Liao, Hong Bing Sun, Ling Yi Kong, and Hao Hong*. Antidiabetic drugs restore abnormal transport of amyloid-β across the blood-brain barrier and memory impairment in db/db mice. Neuropharmacology. In Press.
3. Tang SS, Ji MJ, Chen L, Hu M, Long Y, Li YQ, Miao MX, Li JC, Li N, Ji H, Chen XJ, Hong H*. Protective effect of pranlukast on Aβ1-42-induced cognitive deficits associated with downregulation of cysteinyl leukotriene receptor 1. Int J Neuropsychopharmacol. 2014 ;17(4):581-92.
4. Tang SS, Hong H*, Chen L, Mei ZL, Ji MJ, Xiang GQ, Li N, Ji H. Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo. Neurobiol Aging. 2014;35(3):590-9.
5. Lai J, Hu M, Wang H, Hu M, Long Y, Miao MX, Li JC, Wang XB, Kong LY, Hong H*. Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice. Neuropharmacology. 2014;79:707-14.
6. Wang H, Mei ZL, Zhong KL, Hu M, Long Y, Miao MX, Li N, Yan TH, Hong H*. Pretreatment with antiasthmatic drug ibudilast ameliorates Aβ1-42-induced memory impairment and neurotoxicity in mice. Pharmacol Biochem Behav. 2014；124:373–379.
7. Lai J, Mei ZL, Wang H, Hu M, Long Y, Miao MX, Li N, Hong H*. Montelukast rescues primary neurons against Aβ1-42-induced toxicity through inhibiting CysLT1R-mediated NF-κB signaling. Neurochem Int. 2014 ;75:26-31. (IF:2.659)
8．Du GT, Hu M, Mei ZL, Wang C, Liu GJ, Hu M, Long Y, Miao MX, Chang Li J, Hong H*.
Telmisartan treatment ameliorates memory deficits in streptozotocin-induced diabetic mice via attenuating cerebral amyloidosis. J Pharmacol Sci. 2014;124(4):418-26.
9. Tang SS, Wang XY, Hong H*, Long Y, Li YQ, Xiang GQ, Jiang LY, Zhang HT, Liu LP, Ji H. Leukotriene D4 induces cognitive impairment through enhancement of CysLT₁ R-mediated amyloid-β generation in mice. Neuropharmacology. 2013; 65:182-92. (IF:4.114)
10. Wang XY, Tang SS, Hu M, Long Y, Li YQ, Liao MX, Ji H, Hong H*. Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. Neurochem Int. 2013; 62(3):340-7.
11. Liu LP, Yan TH, Jiang LY, Hu W, Hu M, Wang C, Zhang Q, Long Y, Wang JQ, Li YQ, Hu M, Hong H*. Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation. Acta Pharmacol Sin. 2013; 34(4):455-63.
12. Xiang GQ, Tang SS, Jiang LY, Hong H*, Li Q, Wang C, Wang XY, Zhang TT, Yin L. PPARγ agonist pioglitazone improves scopolamine-induced memory impairment in mice. J Pharm Pharmacol. 2012; 64(4):589-96.
13. Jiang LY, Tang SS, Wang XY, Liu LP, Long Y, Hu M, Liao MX, Ding QL, Hu W, Li JC, Hong H*. PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus. CNS Neurosci Ther. 2012; 18(8):659-66.