中国药科大学

姓名：柳晓泉

性别：男

学科专业：药物动力学

职务职称：教授

最高学历及毕业时间：博士、2001年于中国药科大学药代中心获得博士学位

联系方式：025-83271260

学习经历：1984年于南京药学院药学系获学士学位

1989年于中国药科大学获硕士学位

2001年于中国药科大学获博士学位

工作经历：1984～1992年中国药科大学药理教研室任助教

1992～1996年中国药科大学药代中心任讲师

1996～2002年中国药科大学药代中心任副教授

2003～至今中国药科大学药代中心任教授

专业研究方向：药物动力学

①具体研究领域：致力于药物代谢动力学基础理论和应用的研究，以药物代谢动力学新理论、新模型、新技术和新方法的研究及其在新药开发研究中的应用为主要的研究方向。目前主要研究方向包括：

1．药动学和药效学结合模型研究

2．创新药物的药代动力学研究

②课题资助：目前承担两项国家自然科学基金资助项目

③所获成果：2004年获得江苏省科技进步一等奖一项（创新药物体内吸收、代谢、分布与排泄新理论与新模型研究）；2007年获得国家科技进二等奖一项（临床前药物代谢动力学关键技术与研究体系）；

④研究生培养：培养硕士研究生25名，目前在读硕士11名；培养博士研究生4名，目前在读博士生4名。

⑤近期代表性论文及成果等：

1.Hua He,, Xi Li, Haidong Wang, Wenting Zhang, Huiyong Jiang,Shijun Wang,Linhua Yuan, Yao Liu, and Xiaoquan LiuEffects of Salvianolic Acid A on Plasma and Tissue Dimethylarginine Levels in a Rat Model of Myocardial Infarction J Cardiovasc Pharmacol 2013：61：482-488

2.Hua He, Shijun Wang, Xi Li, Haidong Wang, Wenting Zhang, Linhua Yuan, Xiaoquan Liu A novel metabolic balance model for describing the metabolic disruption of and interactions between cardiovascular-related markers during acute myocardial infarction  Metabolism 2013；62：1357-1366

3.Chen Y, Cao Y, Zhou J, Liu X  Mechanism-based pharmacokinetic- pharmacodynamic  modeling of bidirectional effect of danshensu on plasma homocysteine in rats.  Pharm Res 2009 ;26(8):1863-73.

4.Cao Y, Chai JG, Chen YC, Zhao J, Zhou J, Shao JP, Ma C,Liu XD,Liu XQ  Beneficial effects of danshensu, an active component of silvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration  pathway in rat. Br J Pharmacol 2009;157(3):482-90

5． Wang H, Ma C, Zhou J, Liu XQ.Stereoselective analysis of tiopronin enantiomers in rat plasma using high-performance liquid chromatography-electrospray ionization mass spectrometry after chiral derivatization.  Chirality 2009;21(5):531-8.

6．Cao YG, Zhang L，Ma C, Chang BB, Chen YC, Tang YQ, Liu XD, Liu XQ  Metabolism of protocatechuic acid influence fatty acid oxidation in rat heart: new anti-angina mechanism implication Biochem Pharmacol 2009;77(6):1096-1104

7． Cao YG, Chen YC，Hao K , Zhang M, Liu XQ  An in vivo approach for globally estimation the drug flow between blood and tissue foe nafamostat mesilate: the main hydrolysis site determination in human. Biol Pharm Bull 2008;35(11): 1985-1989.

8．Wang H, Chen Y, Zhou J, Ma C, Chen YC, Liu XQ. Stereoselective determination of ornidazole enantiomers in human plasma and urine samples by chiral LC: application to pharmacokinetic study  Chromatographia 2008;67(11/12):875-881

9． Cao YG, Zhang M, Yu D, Shao JP, Chen YC, Liu XQ  A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: more accurate evaluation for pharmacokinetic study. Anal Bioanal Chem. 2008;391 (3):1063-71.

10．Hao K, Liu XQ, Wang GJ， Zhao XP  Pharmacokinetics, tissue distribution and excretion of gambogic acid in rat. Eur J Drug Metab Pharmacokinet 2007;32(2):63-68

11．Ge lin, Jun Tang, Xiaoquan Liu, Yang Jian and Jiang Zheng Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes.  Drug Metab Dispos,2007;35(4):607-613

12．Hao K, Zhao XP, Liu XQ, Wang GJ   Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study.  Biomed Chromatogr. 2007;21(3):279-283

13．Hao K, Chen YC, Cao YG, Liu XQ, Wang GJ Pharmacokinetic-pharmacodynamic modeling of telmisartan using an indirect response model in spontaneously hypertensive rats.  Acta Pharmacol Sin. 2007；28(5):738-43

14．Cao YG, Liu XQ, Chen YC, Hao K, Wang GJ  Warfarin maintenance dose adjustment with indirect pharmacodynamic model in rats.Eur J Pharm Sci.2007；30（2）：175-180

15．Zhao XP, Zhong J, Liu XQ, Wang GJ  CYP3A4 mediated in vitro metabolism of vinflunine in human liver Microsomes.  Acta Pharmacol Sin. 2007;28(1):118-24

16．J Zhong, X.Q. Liu, Y. Chen, X.P. Zhao, Y.S. Wang, G.J. Wang  Determination of renolazine in rat plasma by liquid chromatography- electrospray ionization mass spectrometry Chromatographia 2006;63(3/4):123-127

17．Zhao X，Liu X, Wang Y， Chen Y， Wang G  Determination of vinflunine in rat plasma by liquid chromatography- electrospray ionization mass spectrometry for a pharmacokinetic study J Pharm Biomed Anal 2006;41(3):906-911

18．Liu YT, Hao K, Liu XQ, Wang GJ.  Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes.  Acta Pharmacol Sin 2006;27(9):1253-1258

19．Zhao XP, Liu XQ, Wang YS, Wang H, Wang GJ.  Pharmacokinetics, tissue distribution and excretion of vinflunine. Eur J Drug Metab Pharmacokinet 2006;31(2):59-64

20. Chen Y, Liu XQ, Zhong J, Zhao X, Wang Y, Wang G. Stereoselective pharmacokinetics of ornidazole after intravenous administration of individual enantiomers and the racemate.  Chirality 2006；18（10）：799-802

21. K Hao, XP Zhao, XQ Liu, GJ Wang  LC determination of curcumin in dog plasma for a pharmacokinetic study.  Chromatographia 2006;64(9/10):531-535

22. Yongsheng Wang, Xiaoping Zhao, Jiao Zhong, Xiaoquan Liu, Guangji Wang Simple determination of pirfenidone in rat plasma via high-performance liquid chromatography. Biomed Chromatogr 2006;20:1375-1379