中国药科大学

张广钦,男，博士，副研究员，硕士生导师。

E-mail:njzhanggq@163.com

025-83271070(办)

受教育经历：

2001/10-2003/10，北京大学，生命科学学院，博士后
1997/09-2001/06,中国药科大学,药学院，博士
1989/09-1992/06,中国药科大学,药学院，硕士
1982/09-1985/06,河南大学，药学系

研究工作经历：

2009/10-2010/11，新加坡国家心脏中心，研究科学家
2005/01-2006/01，香港科技大学，生化系，博士后
2001/10-2003/10，北京大学，生命科学学院，博士后
2004/11-目前，中国药科大学,药学院，副研究员
1992/07-2001/09，中国药科大学,药学院，讲师
1985/8-1989/8，河南商丘地区中医院，药剂师

主要研究领域：

1.心肌和神经细胞离子通道研究以及细胞钙信号转导。
2.诱导性多潜能干细胞(iPS)定向心肌细胞分化的研究。

近几年发表的主要论文：

1.Zhang GQ, Wei H, Lu J, Wong P, Shim W. Identification and characterization of calcium sparks in cardiomyocytes derived from human induced pluripotent stem cells. PLoS One. 2013;8(2):e55266.
2.Wei H, Zhang G, Qiu S, Lu J, Sheng J, Manasi, Tan G, Wong P, Gan SU, Shim W. Hydrogen sulfide suppresses outward rectifier potassium currents in human pluripotent stem cell-derived cardiomyocytes. PLoS One. 2012;7(11):e50641.(并列作者).
3.Ma D, Wei H, Lu J, Ho S, Zhang G, Sun X, Oh Y, Tan SH, Ng ML, Shim W, Wong P, Liew R. Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J. 2013；34(15):1122-33..
4.Shim W, Mehta A, Lim SY, Zhang G, Lim CH, Chua T, Wong P. G-CSF for stem cell therapy in acute myocardial infarction: friend or foe? Cardiovasc Res. 2011;89(1):20-30.
5.Zhang GQ, Qiu SH, Wei HM.Scutellarin blocks sodium current in freshly isolated mouse hippocampal CA1 neurons. Neurochem Res. 2011, 36:947-54.
6.Zhang GQ, Wang H, Liu WT, Dong H, Fong WF, Tang LM, Xiong YH, Yu ZL, Ko KM. Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis.Rejuvenation Res. 2008, 11: 991-1000.
7.Zhang GQ, Huang XD, Wang H, Leung AK, Chan CL, Fong DW, Yu ZL. Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips. J Ethnopharmacol. 2008;118:290-4.
8.Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ. Temperature dependence and thermodynamic properties of Ca2+ sparks in rat cardiomyocytes. Biophys J. 2005;89:2533-41
9.Zhang Guangqin, Fu Yu, Yang Dongmei, Hao Xuemei, Bai Shuhua, Tang Yiqun, Edward G Lakatta, Cheng Heping. Contribution of Spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocyte. Science in China (C) 2004;47(1):31-8
10. ZHANG Guang-Qin, HAO Xue-Mei, DAI De-Zai, FU Yu, ZHOU Pei-Ai, WU Cai-Hong. Puerarin blocks Na+ current in isolated rat ventricular myocytes. Acta Pharmacol Sin 2003; 24(12): 1212-6
11. ZHANG Guang-Qin, HAO Xue-Mei, CHEN Shi-Zhong, ZHOU Pei-Ai, CHENG He-Ping, WU Cai-Hong. Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons. Acta Pharmacol Sin. 2003; 24(12):1248.-52
12. G-Q Zhang, X-M Hao, P-A Zhou, C-H Wu. Effect of paeonol on L-type calcium channel in rat ventricular myocytes. Mothods Find Exp Clin Pharmacol 2003; 25(4):281-5
 13. ZHANG Guang-Qin, HAO Xue-Mei, ZHOU Pei-Ai, WU Cai-Hong, DAI De-Zai.Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. Acta Pharmacol Sin 2001; 22(3):253-6.
14. Zou L.Y., Hao X.M., Zhang G.Q., Zhang M., Guo J.H., Liu T.F.: Effect of Tetramethyl Pyrazine on L-type Calcium Channel in Rat Ventricular Myocytes. Can. J. Physiol. Pharmacol 2001; 79: 621-6.

参与国家级科研项目：

1．心律失常离子通道病变特征ERG基因表达及突变。国家自然科学基金资助项目。NO：39870088
2．改造槲皮素及葛根素优化组合治疗缺血性心律失常的活性。国家自然科学基金资助项目。NO：39970850
3．钙火花与心脏衰老及钙火花学中若干基本问题的研究。国家重点基础研究发展规划资助项目（973项目）。NO:G2000057002
4．钙调蛋白调节心肌兴奋－收缩耦联的分子机制。NO:30200088

获奖情况：

获得2001年度中国高校科学技术奖自然科学二等奖
获得2004年中华医学科技奖三等奖