中国药科大学

陈莉，女，教授，博导。1988年本科毕业于中国药科大学化学制药专业；2004年博士毕业于中国药科大学药物化学专业。

中国药学会会员，九三学社成员，江苏省教育厅青蓝工程中青年学术带头人，2012年4月-2013年4月于美国伊利诺伊大学芝加哥校区（University of Illinois Chicago）从事访问学者研究。国家自然科学基金化学部同行评审专家，Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry , Bioorganic & Medicinal Chemistry Letters 等杂志审稿人。主持及参与国家自然科学基金面上项目、江苏省自然科学基金面上项目、江苏省青蓝工程中青年学术带头人培养对象项目、天津市应用基础及前沿技术研究计划资助项目重点项目及“十一五”重大新药创制等数项国家及省部级科研项目。在Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry，Bioorganic & Medicinal Chemistry Letters, Chemical Biology & Drug Design, Journal of Asian Natural Products Research, Chinese Chemical Letters, Mini-Reviews in Organic Chemistry等国内外重要刊物发表学术论文数十篇。

研究方向

01天然产物结构修饰、改造和生物活性研究
02天然药物与中药的活性成分研究

主持及参与的基金和人才计划项目

1.国家自然科学基金面上项目：新型NO/五环三萜杂合物的分子构建及生物活性评价（No.2097210，主持）
2.江苏省自然科学基金面上项目：基于NO的抗肝癌三萜衍生物分子设计及活性相关性（No.BK2009302，主持）
3.江苏省青蓝工程中青年学术带头人培养对象项目：NO供体型白桦酯酸衍生物的设计、合成及生物活性研究（主持）
4.天津市应用基础及前沿技术研究计划资助项目重点项目：新型肝靶向性三萜衍生物的合成及生物活性研究（No.JCZDJC21400，第二）
5.“十一五”重大新药创制：新型抗血栓和脑缺血候选药物ZJM-289的研究（参加）

代表性论文(均为通讯作者或第一作者)

1. Li LH, Zhao P, Hu JL, Liu JH, Liu Y, Wang ZQ, Xia YF*, Dai Y, Chen L*. Synthesis, in vitro and in vivo antitumor activity of scopoletin-cinnamic acid hybrids. Eur J Med Chem, 2015, 93: 300-307.
2. Ling Y，Wang ZQ，Wang XM，Li XH，Wang XY，Zhang W，Dai H*，Chen, L*，Zhang YH. Hybrid molecule from FTS-diamine and phenylpropenoic acid as Ras-related signaling inhibitor with potent antitumor activities. Chem Biol Drug Des. 2015; 85: 145–152.
3. Liu JH, Zhu ZF, Tang J, Jiang AQ*, Hu LF, Chen L*. Novel NO-releasing derivatives of betulinic acid with antitumor activity, Chin Chem Lett, 2015, 26: 759-762.
4. Zhao P, Chen L (共同第一), Li LH, Wei ZF, Tong B, Jia YG, Kong LY, Xia YF*, Dai Y*. SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. BMC Cancer, 2014, 14: 987-999.
5.Wang TT, Liu Y, Chen L*. Synthesis and cytotoxic activity of nitric oxide-releasing isosteviol derivatives. Bioorg. Med. Chem. Lett., 2014, 24: 2202-2205.
6. Liu JH, Tang J, Zhu ZF, Chen L*. Design, synthesis, and anti-tumor activity of novel betulinic acid derivatives. J Asian Nat Prod Res, 2014, 1: 34-42.
7. Wang ZQ, Chang RA, Huang HY, Wang XM，Wang XY, Chen L*, Ling Y*. Synthesis and biological evaluation of novel farnesylthiosalicylic acid/salicylic acid hybrids as potential anti-tumor agents. Chin Chem Lett,2014, 25:1545-1549.
8. Luo QF, Liu JH, Chen L*. Recent Advance in Enone and NO-Releasing Derivatives of Oleanolic Acid with Anti-cancer Activity, mini-review in organic chemistry, 2014, 11 (3): 355-361.
9. Chen L, Qiu W, Tang J, Wang ZF, He SY. Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives. Chin. Chem. Lett., 2011, 22(4), 413-416,
10. Chen L, Zhu ZF, Meng F, Xu CS, Zhang YH. Synthesis and cytotoxicity of oleanolic acid/N-aryl-N-hydroxyguanidine hybrids. Chin J Nat Med, 2010, 8 (6): 436-440.
11. Chen, L.; Zhang, Y.; Kong, X.; Lan, E.; Huang, Z.; Peng, S.; Kaufman, D. L.; Tian, J. Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. J Med Chem，2008, 51, 4834-4838.
12. Chen, L.; Zhang, Y.; Kong, X.; Peng, S.; Tian, J. Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Bioorg Med Chem Lett , 2007, 17, 2979-2982.

联系方式

Tel：13814083082；E-mail：chenliduo12@gmail.comorchenliduo@sohu.com

通讯地址：南京市童家巷24号，中国药科大学天然药化教研室，邮编210009