兰州大学

姓名：郭玎玎(女)

职称职务：副教授

电子邮箱：guodd@lzu.edu.cn

学习与工作经历

1997年9月-2001年7月吉林农业大学，动物科技学院，获学士学位

2001年9月-2004年7月延边大学，动物分子遗传学，获硕士学位

2005年3月-2010年2月韩国首尔国立大学，医用高分子与组织工学，获博士学位

2010年3月~2011年2月韩国首尔国立大学，作博士后研究

2011年2月~至今兰州大学药学院，微生物与生化药学研究所工作，副教授，硕导

教学工作与成果

科研项目与成果

已发表的论文：

[1]Ding-DingGuo,Seong-HoHong,Hu-LinJiang,Ji-HyeKim,ArashMinai-Tehrani,Ji-EunKim,Ji-YoungShin,TaoJiang,You-KyoungKim,Yun-JaieChoi,Chong-SuChoandMyung-HaingCho.SynergisticeffectsofAkt1shRNAandpaclitaxel-incorporatedconjugatedlinoleicacid-coupledpoloxamerthermosensitivehydrogelonbreastcancer.Biomaterials,2012,33,2272-2281.
[2]Ding-DingGuo,Cheng-XiongXu,Ji-ShanQuan,Chung-KilSong,HuaJin,Dae-DukKim,Yun-JaieChoi,

Myung-HaingChoandChong-SuCho.Synergisticanti-tumoractivityofpaclitaxel-incorporatedconjugated

linoleicacid-coupledpoloxamerthermosensitivehydrogelinvitroandinvivo.Biomaterials,2009,30(27),4777-4785.
[3]Ding-DingGuo,Hyun-SeukMoon,RohidasArote,Ji-HyeSeo,Ji-ShanQuan,Yun-JaieChoi,Chong-SuCho.

EnhancedanticancereffectofconjugatedlinoleicacidbyconjugationwithPluronicF127onMCF-7breast

cancercells.CancerLetters,2007,254(2),244-254.
[4]Hyun-SeukMoon,Ding-DingGuo,Hong-GuLee,Yun-JaieChoi,Jae-SeongKang,KyungminJo,Jeong-Min

Eom,Cheol-HeuiYunandChong-SuCho.Alpha-eleostearicacidsuppressesproliferationofMCF-7breast

cancercellsviaactivationofPPARγandinhibitionofERK1/2.CancerScience,2010,101(2),396-402.
[5]Hyun-SeukMoon,Ji-HyeSeo,Ding-DingGuo,Hong-GuLee,PratiBajracharya,Yun-JaieChoi,Keun-Soo

Jeon,Chong-RaeParkandChong-SuCho.OxidativeStabilizationofConjugatedLinoleicAcidbyOne-pot

PEGylation.MacromolecularResearch,2011,19(8),822-826.
[6]WooKyunBae,JiHeeLee,SangJoonLee,MyongSukPark,JunEulHwang,HyunJeongShim,Sang

HeeCho,Ding-DingGuo,Chong-SuCho,In-KyuParkandIkJooChung.EnhancedAnti-CancerEffectof

5-FluorouracilLoadedintoThermo-ResponsiveConjugatedLinoleicAcid-IncorporatedPoloxamerHydrogel

onMetastaticColonCancerModels.JournalofNanoscienceandNanotechnology11,1425-1428,2011.
[7]KangMiLan,Hu-linJiang,DingDingGuo,ChongSooCho,SangGyunKang,DeogYongLee,Nabin

Rayamahji,YeonSooSeo,

HanSangYoo.ChitosanMicrospheresContainingBordetellabronchisepticaAntigensasNovelVaccine

AgainstAtrophicRhinitisinPigs.JournalofMicrobiologyandBiotechnology2008,18(6):1179-1185.
[8]Ji-HyeSeo,Hyun-SeukMoon,In-YongKim,Ding-DingGuo,Hong-GuLee,Yun-JaieChoi,Chong-SuCho.

PEGylatedconjugatedlinoleicacidstimulationofapoptosisviaap53-mediatedsignalingpathwayinMCF-7

breastcancercells.EuropeanJournalofPharmaceuticsandBiopharmaceutics,2008,70(2),621-626.
[9]Hyun-SeukMoon,Hong-GuLee,Ji-HyeSeo,Ding-DingGuo,In-YongKim,Chung-SooChung,Tae-Gyu

Kim,Yun-JaieChoi,Chong-SuCho.LipolysisisstimulatedbyPEGylatedconjugatedlinoleicacidthroughthe

cyclicadenosinemonophosphate-independentsignalingpathwayin3T3-L1cells:ActivationofMEK/ERK

MAPKsignalingpathwayandhyper-secretionofadipo-cytokines.JournalofCellularPhysiology,2008,

214(2),283-294.
[10]Ji-ShanQuan,Hu-LinJiang,Eun-MiKim,Hwan-JeongJeong,Yoon-JaieChoi,Ding-DingGuo,Mi-Kyong

Yoo,Hong-GuLeeandChong-SuCho.pH-sensitiveandmucoadhesivethiolatedEudragit-coatedchitosan

microspheres.InternationalJournalofPharmaceutics.2008,359(1-2),205-210.
[11]Hyun-SeukMoon,Hong-GuLee,Ji-HyeSeo,Ding-DingGuo,In-YongKim,Chung-SooChung,Tae-GyuKim,

Yun-JaieChoi,Chong-SuCho.LipolysisisstimulatedbyPEGylatedconjugatedlinoleicacidthroughthecyclic

adenosinemonophosphate-independentsignalingpathwayin3T3-L1cells:ActivationofMEK/ERKMAPKsignaling

pathwayandhyper-secretionofadipo-cytokines.JournalofCellularPhysiology,2008,214(2),283-294.
[12]Hyun-SeukMoon,Hong-GuLee,Ji-HyeSeo,Chung-SooChung,Ding-DingGuo,Tae-GyuKim,Yun-JaieChoi,

Chong-SuCho.Leptin-inducedmatrixmetalloproteinase-2secretionissuppressedbytrans-10,cis-12conjugated

linoleicacid.BiochemicalandBiophysicalResearchCommunications.2007,356(4),955-960.
[13]Hyun-SeukMoon,Ding-DingGuo,Ho-HyunSong,In-YongKim,Hu-LinJiang,You-KyoungKim,Chung-Soo

Chung,Yun-JaieChoi,Hong-KuLeeandChong-SuCho.RegulationofadipocytedifferentiationbyPEGylated

all-transretinoicacid:reducedcytotoxicityandattenuatedlipidaccumulation.JournalofNutritionalBiochemistry,

2007,18(5),322-331.
[14]MiLanKang,Hu-LinJiang,SangGyunKang,Ding-DingGuo.PluronicF127enhancestheeffectasanadjuvant

ofchitosanmicrospheresintheintranasaldeliveryofBordetellabronchisepticaantigenscontainingdermonecrotoxin.

Vaccine,2007,25(23),4602-4610.
[15]Seog-JinSeo,Hyun-SeukMoon,Ding-DingGuo,Sang-HeonKim,ToshihiroAkaikecandChong-SuCho.Receptor

-mediateddeliveryofall-trans-retinoidacid(ATRA)tohepatocytesfromATRA-loadedpoly(N-p-vinylbenzyl-4-o-β-d-

galactopyranosyl-d-gluconamide)nanoparticles.MaterialsScienceandEngineering:C,2006,26(1),136-141.
[16]Chong-SuCho,Ding-DingGuo,Hu-LinJiang,You-KyoungKim,Yun-JaieChoiandMyung-HaingCho.Design

ofdegradablepolyethyleniminesasDNAandsiRNAcarriersinvitroandinvivo.JournaloftheNationalAcademyof

SciencesRepublicofKorea,2010,49(1),293-322.
[17]Ding-DingGuo,RohidasArote,Hu-LinJiang,Mi-KyongYoo,Hyun-SeukMoon,Chong-SuCho.Releaseof

All-TransRetinoicAcid(RA)fromRA-loadedPoly(esteramine)BasedonPolyethylenimineandPolycaprolactonefor

IntracellularDelivery.KeyEngineeringMaterials.2007,342-343,429-432.
[18]Ji-HyeSeo,Hyun-SeukMoon,Ding-DingGuo,Hong-GooLee,Yun-JaieChoi,Chong-SuCho.PEGylationof

ConjugatedLinoleicAcidandItsApplicationasanAnti-CancerProdrug.KeyEngineeringMaterials.2007,342-343,441-444.

参编书籍

Ji-ShanQuan,Hu-LinJiang,Jia-HuiYu,Ding-DingGuo,RohidasArote,Yun-JaieChoiandChong-SuCho.Nanoparticles:

NewResearch.Chapter13:PolymericNanoparticlesforOralDeliveryofProteinDrugs.ISBN:978-1-60456-704-5.2008,

NovaSciencePublishers,Inc.

研究与招生方向

招生方向：微生物与生化药学研究方向

研究方向：非病毒基因载体的研究；医用高分子材料；生物制药