北京科技大学

董海峰

北京科技大学教授/博导，生物工程与传感技术研究中心副主任

办公地点：化生楼306

办公电话：010-82376576

电子邮件：hfdong@ustb.edu.cn

科研方向：生物传感，药物运输，纳米药物

社会职务：中国生物检测检测联盟理事; 中国自由基生物学与自由基医学专业委员会青年委员 中国医学生物技术协会生物诊断分会“生物诊断新技术与新材料”委员

简历

2005年与2008年分别获得三峡大学学士和重庆大学硕士学位。2011年获南京大学分析化学获博士学位(导师：鞠熀先教授)，匹兹堡大学博士后(2012.10-2013.9)，京都大学高级访问教授(2015，7-10)。北京科技大学师资博士后(2011.7-2013.9，合作导师，张学记)，北京科技大学生物传感中心特聘教授(2013.10-2014.07)，北京科技大学教授、博导(2014.8-至今)。

科研业绩

2010年以来，在Chem. Rev., Angew. Chem., ACS Nano, Adv. Funct. Mater., Chem. Sci. Anal. Chem.等杂志发表SCI论文65篇，IF论文被包括Nature Chem., Chem. Rev., Angew. Chem. In. Ed等杂志引用2500余次。现为RSC advances Panel Reviewer，《分析仪器》编委。出版中英文专著各一本。 代表性基金： 1. 国家自然基金面上项目“二维过渡金属碳化物/氮化物纳米探针核酸标志物分析” 21874008， 2019-01-01至2022-12-31 , 64 万 2. 国家重点研发计划“数字诊疗装备研发” 专项，2016YFC0106602， “芯片-质谱创新技术平台对循环肿瘤核酸标志物的扩增放大与定量分析在临床应用中的方案” 2016/01-2018/12，212万，子课题负责人 3. 北京食品营养与人类健康高精尖创新中心开放课题，20171002，“食品安全检测及分析方法研究”2017/08-2019/07，30万，主持 4. 国家自然科学基金应急项目，21645005，“乳腺癌“液相组织切片”循环肿瘤DNA的检测新方法研究”2017/01-2017/12，10 万 已结题，主持 5. 国家自然基金-青年基金，21305008，新型多功能贵金属纳米探针与microRNA高效检测新方法的研究，2014/01-2016/12，25，万已结题，主持 6. 中国博士后基金特别资助，2012T50042，肿瘤细胞内MicroRNA成像分析，2013/01-2014/12，15万，已结题，主持

获得奖励/专利

曾获2012年江苏省百篇优秀博士论文、2013年全国百篇优秀博士学位论文提名、2013年教育部自然科学一等奖，2014，2018年中国分析测试协会科技一等奖。 专利： 1.一种基于硫化铜的热消融作用介导的经皮给药的方法，发明专利，董海峰，王冬冬，卢惠婷，201810195852 .9 2.利用琼脂糖凝胶电泳可视化检测多种miRNAs的方法，发明专利，董海峰，代文浩，201810351048 .5 3. 一种单层荧光纳米二硫化钼的制备方法 201410574973.6，2014.10.23

招生计划

每年招收1-2名博士研究生，3名硕士研究生

代表性论文论著

专著：

1. 鞠熀先, 董海峰, 张学记, 核酸检测：DNA与microRNA检测方法, 知识产权出版社, 242千字，2015

2. Xueji Zhang, Haifeng Dong, Yaping Tian. MicroRNA detection and Pathological Function, Springer，37.4 千字，2015

代表性论文

1. Fan Yang, Yaru Cheng, Yu Cao, Haifeng Dong*ab, Huiting Lu, Kai Zhang, Xiangdan Meng, Conghui Liu, and Xueji Zhang* bSensitively Distinguish Intracellular Precursor and Mature MicroRNA Abundance.Chemical Science,

SC-EDG-07-2018-003305.R1 accepted

2. Huiting Lu, Fan Yang, Benhan Liu, Kai Zhang, Yu Cao,Wenhao Dai, Wenjun Li* and Haifeng Dong.* Intracellular low-abundance microRNA imaging by a NIR-assisted entropy-driven DNA system. Nanoscale Horizons. 2018, DOI: 10.1039/C8NH00330K, in press

3. Kai Zhang, Yuedong Zhang, Xiangdan Meng, Huiting Lu, Huan Chang,Haifeng Dong,* Xueji Zhang* Biomaterials, 2018, 185, 301-309

4. Kai Zhang, Xiangdan Meng, Yu Cao, Zhou Yang,* Haifeng Dong,* Yuedong Zhang, Huiting Lu, Zhuojie Shi, and Xueji Zhang Metal-Organic Framework Nanoshuttle for Synergistic Photodynamic and Low-Temperature Photothermal Therapy. Advanced Functional Materials. 2018, 28, 1804634

5. Conghui Liu, Chao Chen, Shuzhou Li, Haifeng Dong,* Wenhao Dai, Tailin Xu, Yang Liu, Fan Yang and Xueji Zhang. Analytical Chemistry, 2018, 90, 10591-10599.

6. Xiangdan Meng, Kai Zhang, Wenhao Dai, Yu Cao, Fan Yang, Haifeng Dong * and Xueji Zhang* Multiplex microRNA imaging in living cells using DNA-capped-Au assembled hydrogels. Chemical Science 2018, 9, 7419-7425

7. Dongdong Wang, Haifeng Dong *, Meng Li, Yu Cao, Fan Yang, Kai Zhang, Wenhao Dai, Changtao Wang, Xueji Zhang * Erythrocyte−cancer hybrid membrane camouflaged hollow copper sulfide nanoparticles for prolonged circulation life and homotypic-targeting photothermal/ chemotherapy of melanoma. ACS Nano, 2018, 12 (6), 5241-5252

8. Wenhao Dai, Jing Zhang, Xiangdan Meng, Jie He, Kai Zhang, Yu Cao, Dongdong Wang, Haifeng Dong,* Xueji Zhang * Catalytic hairpin assembly gel assay for multiple and sensitive microRNA detection.Theranostics, 2018, 8(10), 2646-2656.

9. Yu Cao, Haifeng Dong , Shaotao Pu, and Xueji Zhang  Photoluminescent two-dimensional SiC quantum dotsfor cellular imaging and transport.

Nano Research 2018,11(8), 4074-4081

10. Yu Cao, Shuzhou Li, Chao Chen, Dongdong Wang, Tingting Wu, Haifeng Dong, * Xuej Zhang,*

Rattle-type Au@Cu2−xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy.

Biomaterials. 2018, 158, 23-33.

11. Xiangdan Meng, Wenhao Dai, Kai Zhang, Haifeng Dong* and Xueji Zhang.*

Imaging Multiple MicroRNAs in Living Cell by ATP Self-Powered Strand-Displacement Cascade Amplification.

Chemical Science, 2018,

9, 1184 -1190

12. Wenhao Dai, Haifeng Dong,* Keke Guo and Xueji Zhang.*

Near-Infrared Triggered Strand Displacement Amplification for MicroRNA Quantitative Detection in Single Living Cell.

Chemical Science,

2018, 9, 1753 - 1759

13. Xiangdan Meng, Zhiqiang Liu, Yu Cao, Wenhao Dai, Kai Zhang, Haifeng Dong*, Xiaoyan Feng* and Xueji Zhang*.

Fabricating Aptamer-Conjugated Pegylated-MoS2/Cu1.8S Theranostic Nanoplatform for Multiplexed Imaging Diagnosis and Chemo-Photothermal Therapy of Cancer.

Advanced Functional Materials 2017，27，1605592.

14. Kai Zhang, HaiFeng Dong,*

Wenhao Dai. Xiangdan Meng, Huiting Lu, Tingting Wu and Xueji Zhang*.

Fabricating Pt/Sn-In2O3 Nanoflower with Advanced Oxygen Reduction Reaction Performance for High-Sensitivity MicroRNA Electrochemical Detection. Analytical Chemistry 2017, 89(1), 648-655.

15. Wenhao Dai, Haifeng Dong*, Bunshi Fugetsu, Yu cao, Huiting Lu, Xinlei Ma and Xueji Zhang*.

Tunable Fabrication of Molybdenum Disulfide Quantum Dots for Intracellular MicroRNA Detection and Multiphoton Bioimaging. Small 2015, 11(33), 4158-4164.

16. Haifeng Dong, Xiangdan Meng, Wenhao Dai, Yu Cao, Huiting Lu, Shu-Feng Zhou and Xueji Zhang*.

Highly Sensitive and Selective MicroRNA Detection Based on DNA-Bio-Bar-Code and Enzyme-Assisted Strand Cycle Exponential Signal Amplification. Analytical Chemistry 2015, 87(8), 4334-4340.

17. Haifeng Dong, Jianping Lei, Lin Ding, Yongqiang Wen, Huangxian Ju* and Xueji Zhang*. MicroRNA: Function, Detection, and Bioanalysis. Chemical Reviews 2013, 113(8), 6207-6233.

18. Haifeng Dong, Shi Jin, Huangxian Ju, Kaihong Hao, Li-Ping Xu, Huiting Lu, and Xueji Zhang*. Trace and Label-Free MicroRNA Detection Using Oligonucleotide Encapsulated Silver Nanoclusters as Probes. Analytical Chemistry 2012, 84(20), 8670-8674.

19. Haifeng Dong, Jing Zhang, Huangxian Ju*, Huiting Lu, Shiyan Wang, Shi Jin, Kaihong Hao, Hongwu Du and Xueji Zhang*. Highly Sensitive Multiple microRNA Detection Based on Fluorescence Quenching of Graphene Oxide and Isothermal Strand-Displacement Polymerase Reaction. Analytical Chemistry 2012, 84(10), 4587-4593.

20. Haifeng Dong, Jianping Lei, Huangxian Ju*, Huiting Lu, Shiyan Wang, Wenjie Guo, Zhu Zhu and Feng Yan*. Target-Cell-Specific Delivery, Imaging, and Detection of Intracellular MicroRNA with a Multifunctional SnO2 Nanoprobe. Angewandte Chemie International Edition 2012, 124(19), 4685-4690.

21. Haifeng Dong, Lin Ding, Feng Yan*, Hanxu Ji and Huangxian Ju*. The Use of PolyethylenimineCGrafted Graphene Nanoribbon for Cellular Delivery of Locked Nucleic Acid Modified Molecular Beacon for Recognition of MicroRNA. Biomaterials 2011, 32(15), 3875-3882.

22. Haifeng Dong, Feng Yan*, Hanxu Ji, Danny K. Y. Wong* and Huangxian Ju*. Quantum-Dot-Functionalized Poly(styrene-co-acrylic acid) Microbeads: Step-Wise Self-Assembly, Characterization, and Applications for Sub-femtomolar Electrochemical Detection of DNA Hybridization. Advanced Functional Materials 2010, 20(7), 1173-1179.

23. Haifeng Dong, Wenchao Gao, Feng Yan*, Hanxu Ji and Huangxian Ju*. Fluorescence Resonance Energy Transfer between Quantum Dots and Graphene Oxide for Sensing Biomolecules. Analytical Chemistry 2010,82(13), 5511-5517.