河北大学

河北大学化学与环境科学学院研究生导师王书香介绍如下：

一、个人简介

王书香, 男, 生于1965年11月，河北省廊坊大城县人。博士，教授，硕士研究生导师。迄今为止，发表SCI收录论文40余篇;获中国发明专利授权2项，曽主持和参与科研课题多项。2007年度获河北省科技进步三等奖。2014年获河北省自然科学二等奖。

联系方式：E-mail: wsx@hbu.edu.cn

二、主讲课程及研究方向

1.主讲课程：有机化学

2.研究方向：有机合成、药物化学、小分子探针

三、代表性论文

1. Shuxiang Wang*, Wenqing Shao, Hongdong Li, Cui Liu, Ke Wang, Jinchao Zhang*. Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives. Eur J Med Chem., 2011, 46, 1914-1918.

2. Shuxiang Wang, Hongdong Li, Chao Chen, Jinchao Zhang*, Shenghui Li, Xinying Qin, Xiaoliu Li*, Kerang Wang. Cytotoxicity and DNA binding property of phenanthrene imidazole with polyglycol side chains. Bioorg Med Chem Lett., 2012, 22: 6347–6351.

3. Shuxiang Wang*, Yanan Shi, Wenqing Shao, Jianlong Du, Haiying Wei, Jinchao Zhang*, Ke Wang, Shigang Shen, Shenghui Li, Jitai Li and Yangyang Zhao.Synthesis, characterization and cytotoxicity of gold(III) complexes with deprotonated pyridyl carboxamide. Appl. Organometal. Chem. (2012)

4. Yanan Shi, Wenhao Chu, Yuechai Wang, Shuxiang Wang*, Jianlong Du, Jinchao Zhang*, Shenghui Li, Guoqiang Zhou, Xinying Qin, Chenliang Zhang. Synthesis, characterization and cytotoxicity of the Au(III) complexes with cyclic amine-based dithiocarbamate ligands. Inorganic Chemistry

Communications, 2013, 30: 178–181.

5. Shizhu Chen, Yingjian Hou, Gong Cheng, Cuimiao Zhang, Shuxiang Wang*, Jinchao Zhang*. Cerium Oxide Nanoparticles Protect Endothelial Cells from Apoptosis Induced by Oxidative Stress. Biol Trace Elem Res, 2013, 154, 156–166.

6. Shuxiang Wang*, Wenhao Chu, Yuechai Wang, Siyuan Liu, Jinchao Zhang, Shenghui Li, Haiying Wei, Guoqiang Zhou, Xinying Qin. Synthesis, characterization and cytotoxicity of Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4’-substituted terpyridine. Appl Organometal Chem, 2013, 27, 373–379.

7. Wenhao Chu, Yuechai Wang, Siyuan Liu, Xueyun Yang, Shuxiang Wang*, Shenghui Li, Guoqiang Zhou, Xinying Qin, Chuanqi Zhou, Jinchao Zhang*. Synthesis, cytotoxicity and DNA-binding properties of Pd(II), Cu(II) and Zn(II) complexes with 4¢-(4-(2-(piperidin-1-yl)ethoxy)phenyl)- 2,2’:6’,2’’-terpyridine.

Bioorg Med Chem Lett., 2013, 23: 5187–5191.

8. Cui Liu, Siyuan Liu, Yuechai Wang, Shuxiang Wang*, Jinchao Zhang*, Shenghui Li, Xinying Qin,Xiaoliu Li, Kerang Wang,Quoqiang Zhou. Synthesis, cytotoxicity, and DNA-binding property of berberine derivatives. Med Chem Res, 2014, 23:1899–1907.

9. Shizhu Chen, Cuimiao Zhang, Guang Jia, Jianlei Duan, ShuxiangWang*, Jinchao Zhang*. Size-dependent cytotoxicity of europium doped NaYF4nanoparticles in endothelial cells. Materials Science and Engineering C, 2014, 43: 330–342.

四、科研项目

1.2011.01-2013.12: 主持河北省自然科学基金：二茂铁基环Au(III)化合物的设计、合成与抗肿瘤活性研究

2. 2012.01-2014.12: 主持河北省教育厅重点项目：新型Co(III)配合物类乏氧激活性抗肿瘤前药的设计、合成与筛选

3. 2015-2017主持河北省应用基础研究计划重点基础研究项目：茚(1,2-b)喹喔啉-5,10-二氧-11-酮肟醚类乏氧激活性抗肿瘤前药的设计、合成与抗肿瘤机制研究

五、授权专利

1. 发明人：王书香，张金超, 李胜辉，秦新英，宋长英，邵文庆. 具有抗肿瘤活性酰胺类Au(III)配合物、制备方法及应用. 专利号：ZL 201110157868.9