空军军医大学

姓名：李小强

性别：男　

职称：副教授

学院：药学系

李小强，第四军医大学药理学教研室副教授、副主任，硕士研究生导师，陕西省药品保健食品审评专家。中国药理学会、中国生物物理学会和美国生物物理学会会员。1999年毕业于西安交通大学药学院，获学士学位，毕业后参军入伍至第四军医大学药理学教研室工作。2007年6月获第四军医大学医学博士学位（学校首批硕-博连读生）。2006年4月至2008年6月，赴美国Albany医学院心血管科学研究中心进行博士研究生联合培养和博士后研究工作。

目前负责国家自然科学基金课题2项、陕西省科技计划项目1项、分题负责十一五国家“重大新药创制”课题1项，2009年获第四军医大学“青年英才支持计划（第二层次）”研究基金资助；以主要完成人参与其他国家、军队、省部级课题10余项。

发表研究论文43篇，其中SCI收录期刊20余篇；担任Journal of Pharmacy and Pharmacology，International Immunopharmacology，《心脏杂志》和《细胞与分子免疫学杂志》等国内外期刊审稿人；申请国家发明专利2项。

任教以来，主讲药理学、临床药理学、临床药物治疗学等课程，发表教学论文3篇，主编校内教材1部，参编专著4部，2011年获第四军医大学“精品教员”称号；曾多次获嘉奖，荣立个人“三等功”1次。

研究方向：（1）离子通道在相关疾病中调控机制的基础及应用研究；（2）活性天然产物的药理作用及新药研究。
 
发表的主要文章（*为通讯作者）：

1. Li XQ, Cao W, Zeng AG, Yang ZF, Xing B, Dong L, Zhang HF, Mei QB*. Different pharmacological properties of the optical isomers of MN9202, a novel 1,4-dihydropyridine Ca2+ channel modulator in rat ventricular myocytes. Clin Exp Pharmacol Physiol. 2010;37(8):817-825.

2. Li XQ, Zheng YM, Rathore R, Ma J, Takeshima H, Wang YX*. Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells. Pflugers Arch. 2009;457(4): 771-783.

3. Li XQ*, Cao W, Li T, Zeng AG, Hao LL, Zhang XN, Mei QB. Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol. 2009;9(9):1032-1041.

4. Li XQ, Zhao MG, Mei QB*, Zhang YF, Guo W, Wang HF, Chen D, Cui Y. Effects of tumor necrosis factor-alpha on calcium movement in rat ventricular myocytes. Acta Pharmacol Sin. 2003; 24(12): 1224-1230.

5. Li XQ, Zheng YM, Wang YX*. Functional importance of type-1 ryanodine receptor in smooth muscle cells. Biophysical Journal. 2008, 94(2) : 877-880.

6. Cao W, Li XQ*, Zhang XN, Hou Y, Zeng AG, Xie YH, Wang SW*. Madecassoside suppresses LPS- induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity. Int Immunopharmacol. 2010;10(7):723-729.

7. Cao W, Xie YH, Li XQ*, Zhang XK, Chen YT, Kang R, Chen X, Miao S, Wang SW*. Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways. Basic Res Cardiol. 2011 Jun 26.

8. Cao W, Li XQ(co-first), Wang X, Li T, Chen X, Liu SB, Mei QB*. Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels. Int J Biol Macromol. 2010;46(1):115-122.

9. Cao W, Li XQ(co-first), Wang X, Fan HT, Zhang XN, Hou Y, Liu SB, Mei QB*. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. Phytomedicine. 2010;17(8-9):598-605.

10. Cao W, Li XQ, Liu L, Yang TH, Li C, Fan HT, Jia M, Lv ZG, Mei QB*. Structure of an anti-tumor polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydr Polymers. 2006;66(2):149-159.

11. Cao W, Li XQ, Liu L, Wang M, Fan HT, Li C, Lv Z, Wang X, Mei Q*. Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels. Carbohydr Res. 2006; 341 (11):1870-1877.

12. Rathore R, Zheng YM, Li XQ, Wang QS, Liu QH, Ginnan R, Singer HA, Ho YS, Wang YX*. Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in[Ca2+]i in pulmonary artery smooth muscle cells. Biochem Biophys Res Commun. 2006;351(3):784-790.

13. Liu QH, Zheng YM, Li XQ, Ma JJ, Takeshima H, Wang YX*. PKC epsilon Regulates Calcium Sparks By Selectively Interacting With Type-1 Ryanodine Receptors In Smooth Muscle Cells. Biophysical Journal. 2008, 94(2) : 150-157.

14. Liu QH, Zheng YM, Korde AS, Li XQ, Ma J, Takeshima H, Wang YX*. Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. Am J Respir Cell Mol Biol. 2009; 40(6):663-671.

15. Zhao MG, Mei QB, Zhang YF, Xing B, Li XQ, Cui Y. Inhibitory effects of serotonin on transient outward potassium current in rat ventricular myocytes. Acta Pharmacol Sin. 2002;23(7):617-622.