空军军医大学

姓名：周四元

性别：男　

职称：教授

学院：药学系

研究方向：靶向递药系统与药物代谢动力学研究

周四元，男， 2000年获得第四军医大学药理学专业博士学位, 2007-2009在美国康涅狄格州大学从事新药筛选研究。现任第四军医大学药剂学教研室主任，教授，药剂学专业硕士研究生导师，陕西省药理学会常务理事，副秘书长，国家药品价格评审专家。长期从事靶向递药系统与药物代谢动力学研究，发表论文90余篇，其中SCI收录论文18篇，获得国家发明专利3项。2007年获陕西省科技进步一等奖1项（第三）。在靶向递药系统研究方面，2005年获国家科技部药物制剂关键技术研究专项经费支持，针对抗肿瘤化疗药物在临床应用过程中存在的问题，建立了大分子靶向药物研究技术平台，制备肿瘤靶向递药系统，通过药效学及药代动力学评价，可望筛选出肿瘤靶向性好、疗效确切的递药系统。药物代谢动力学研究2003年获得国家科技部创新药物临床前药物代谢动力学关键技术平台建设专项经费支持，建立了肝微粒体、Caco-2细胞、HepG2细胞、原位小肠、肝脏灌流等药物吸收代谢研究模型，以及生物介质中氨氯地平、白藜芦醇苷等近30种药物/代谢产物的HPLC以及LC/MS/MS检测方法。药物代谢动力学研究主要开展以下三个方面工作：（1）药物吸收代谢筛选，（2）天然药物代谢转运机制研究，（3）新药临床前药代动力学研究。

代表论文

1. Liu RW, Teng ZH, Yuan CJ, Huan ML, Liu XY, Zhou SY*. Liquid chromatography/positive-ion electrospray tandem mass spectrometry assay for nisoldipine in human plasma and its application to a pharmacokinetic study. Journal of Liquid Chromatography & Related Technologies.2011, 34(16): 1800-1810.

2. Zhang WD, Wang XJ, Zhou SY*, Gu Y, Wang R, Zhang TL, Gan HQ. Determination of free and glucuronidated kaempferol in rat plasma by LC-MS/MS: application to pharmacokinetic study.J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(23):2137-40.

3. Zhou SY, Mamdani M, Qanud K, Shen JB, Pappano AJ, Kumar ST, Jacobson KA, Hintze T, Recchia F, Liang B. Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac P2X purinergic receptors. J. Pharmacol. Exp. Ther. 2010,333(3):920-8.

4. Kumar TS, Zhou SY, Joshi BV, Balasubramanian R, Yang T, Liang BT, Jacobson KA. Structure-activity relationship of (N)-methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor. J.Med.Chem. 2010, 53(6):2562-76.

5. Zhang BL, He W, Shi X, Huan ML, Huang QJ, Zhou SY*. Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5- dicarboxylate. Bioorg. Med. Chem. Lett. 2010, 20(3):805-8.

6. Liu XY, Teng ZH, Zhang Y, Huan ML, Zhou SY. High performance liquid chromatography-tandem mass spectrometric determination of resveratrol and its metabolites in rat tissues. Analytical Letters. 2010,43(4): 557–569.

7. Zhou S, Yang R, Teng Z, Zhang B, Hu Y, Yang Z, Huan M, Zhang X, Mei Q. Dose-dependent absorption and metabolism of trans-polydatin in rats. J.Agric.Food Chem. 2009, 57(11):4572 -4579.

8. Huan ML, Zhou SY, Mei QB.Conjugation with α-linolenic acid improves cancer cell uptake and cytotoxicity of Doxorubicin. Bioorg.Med.Chem.Lett. 2009, 19(9): 2579-2584.

9.Zhou S, Zhang B, Liu X, Teng Z, Huan M, Yang T, Yang Z, Jia M, Mei Q. A new natural angelica polysaccharide based colon-specific drug delivery system. Journal of Pharmaceutical Science. 2009, 98(12):4756-68.

10.Zhou S, Hu Y, Zhang B, Teng Z, Gan H, Yang Z, Wang Q, Huan M, Mei Q. Dose-dependent absorption, metabolism, and excretion of genistein in rats. J.Agric.Food Chem. 2008, 56(18):8354-9.

11.Sonin D, Zhou SY, Cronin C, Sonina T, Wu J, Jacobson KA, Pappano AJ, Liang BT. Role of P2X purinergic receptors in the rescue of ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008, 295(3):H1191-7.

12.Yang ZF, Zhou SY (co-first author), Yang TH, Liu XY, Mei QB. Pharmacokinetics of the analogs at C3 and C5 of m-nifedipine in beagle dogs. Biopharmaceutics and drug disposition. 2008, 29:485-494.

13.Teng ZH, Zhou SY (co-first author), Yang RT, Liu XY, Liu RW, Yang X, Zhang BL, Yang JY, Cao DY, Mei QB. Quantitation assay for absorption and first-pass metabolism of emodin in isolated rat small intestine using liquid chromatography-tandem mass spectrometry. Biol. Pharm. Bull. 2007, 30(9):1628-1633.

14.Teng ZH, Zhou SY, Ran YH, Liu XY, Liu RW, Yang X, Yuan CJ, Mei QB. Cellular absorption of anthraquinones emodin and chrysophanol in human intestinal Caco-2 cells. Biosci. Biotechnol. Biochem. 2007, 71(7):1636-1643.