兰州大学

学习经历

1996.9－2000.6，兰州大学生物化学专业，学士
2001.9－2006.6，兰州大学生物化学专业，硕博连读，导师：王锐
工作经历 2000.8-2001.7，甘肃榆中恩玲中学，教师，研究生支教工作
2006.7-2011.4，兰州大学生命科学学院，讲师
2011.5-至今，兰州大学生命科学学院，副教授

教学及指导研究生情况

承担本科生《分子生物学》、《生物技术制药》课程。

硕士生导师。

发表论文及专著

Jiang JH, He Z, Peng YL, Jin WD, Wang Z, Han RW, Chang M*, Wang R*. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 doi:10.1016/j.nlm.2015.05.010 (SCI)
Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M*, Wang R*. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39-48. (SCI)
Han RW, Xu HJ, Zhang RS, Wang P, Chang M, Peng YL, Deng KY, Wang R*. Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiol Learn Mem. 2014 ;107:32-6. (SCI)
Han, RW, Zhang RS, Xu HJ, Chang M, Peng YL, Wang R*. Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Abeta42 in mice novel object and object location recognition tasks, Neuropharmacology, 2013;70:261-7.(SCI)
Han RW, Zhang RS, Chang M, Peng YL, Wang P, Hu SQ, Choi CL, Yin M, Wang R*, Han YF. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Res. 2012;1470:59-68. (SCI)
Peng YL, Zhang JN, Chang M, Li W, Han RW, Wang R*. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-83. (SCI)
Peng YL, Han RW, Chang M, Zhang L, Zhang RS, Li W, Han YF, Wang R*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31(12):2259-63. (SCI)
Chang M, Li W, Peng YL, Gao YH, Yao J, Han RW, Wang R*. Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6]γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain Res. 2009;1271:36-48. (SCI)
Li W, Chang M, Peng YL, Gao YH, Zhang JN, Han RW, Wang R*. Neuropeptide S produces antinociceptive effect at the supraspinal level in mice. Regul. Pept. 2009;156:90-5. (SCI)
Han RW, Chang M, Peng YL, Qiao LY, Yin XQ, Li W, Wang R*. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides. 2009;30(7): 1313-17. (SCI)
 Han RW, Yin XQ, Chang M, Peng YL, Li W, Wang R*. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment in mice morris water maze. Neuro. Lett. 2009;455:74-7. (SCI)
Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R*. Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice. Peptides. 2009;30(2):234-40. (SCI)
Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Regulation of Endochondral Ossification by Osteogenic Growth Peptide C-terminal Pentapeptide [OGP(10-14)]. Protein Pept. Lett. 2009;16:1074-80. (SCI)
常民, 彭雅丽, 李威, 王锐. 神经肽S的功能与构效关系研究进展. 生物物理学报. 2009;03:175-82.
Li Z, Zhou LX, Zhang BH, Yan X, Li J, Peng YL, Chang M, Dong SL, Wang R*. Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell.Pharmazie. 2008;63(9):676-85.(SCI)
Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept. 2007;142(1-2):16-23. (SCI)
Peng YL, Chang M, Dong SL, Li W, Han RW, Fu GX, Chen Q, Wang R*. Novel potent agonist [(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 and antagonist [Nphe1,(pF)Phe4, Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 of nociceptin/orphanin FQ receptor. Regul. Pept. 2006;134:75-81. (SCI)
Fang Q, Guo J, Peng YL, Chang M, He F, Chen Q, Wang R*. In vitro and in vivo studies of dansylated compounds, the putative agonists and antagonists on neuropeptide FF receptors. Peptides. 2006;27:1297-304. (SCI)
Yang Q, Chen Y, Fu C, Chang M, Peng YL, Wang R*. Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.Protein Pept Lett. 2006;13(2):185-8.(SCI)

专利：

一种固液相缩合制备胸腺肽α1的方法，申请号：CN201310523706.1；
液相片段缩合制备胸腺肽α1的方法，申请号：CN201310523577.6；
片段缩合制备醋酸鲑鱼降钙素的方法，申请号: CN201410420967.5;
片段缩合制备特利加压素的方法，申请号: CN201410554759.4
一种片段缩合制备曲普瑞林的方法，申请号: CN201410743707.1
一种片段缩合制备醋酸去氨加压素的方法，申请号: CN201410748612.9
一种片段缩合制备醋酸阿托西班的方法，申请号: CN201410802681.3
片段缩合制备利拉鲁肽的方法，申请号：CN201510079168.0

研究方向

1、神经肽

2、多肽合成

3、多肽药理学

项目成果

主持项目：

1、神经肽S与疼痛下行抑制通路关系的研究（30900445）。国家自然科学基金委。

2、一种治疗阿尔茨海默病的新多肽药物的设计和活性研究（0708NKCA111）。甘肃省科技厅。

3、新的胸腺肽α1生产工艺的研究（07-3-08）。兰州市科技局。

参与项目：

1、若干多肽合成和化学修饰的新方法研究及其在多肽药物产业开发中的应用（2009ZX09503）。科技部“重大新药创制”科技重大专项。