兰州大学

姓名：郭玎玎   ( 女 ) 
职称职务：副教授
电子邮箱：guodd@lzu.edu.cn

学习与工作经历

1997年9月-2001年7月      吉林农业大学，动物科技学院，获学士学位
2001年9月-2004年7月      延边大学，动物分子遗传学，获硕士学位 
2005年3月-2010年2月      韩国首尔国立大学，医用高分子与组织工学，获博士学位
2010年3月~2011年2月      韩国首尔国立大学，作博士后研究
2011年2月~至今           兰州大学药学院，微生物与生化药学研究所工作，副教授，硕导

教学工作与成果

科研项目与成果

已发表的论文：
 
[1]    Ding-Ding Guo, Seong-Ho Hong, Hu-Lin Jiang, Ji-Hye Kim, Arash Minai-Tehrani, Ji-Eun Kim, Ji-Young Shin,

Tao Jiang, You-Kyoung Kim, Yun-Jaie Choi, Chong-Su Cho and Myung-Haing Cho. Synergistic effects of Akt1

shRNA and paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel on

breast cancer. Biomaterials, 2012, 33, 2272-2281. 
[2]    Ding-Ding Guo, Cheng-Xiong Xu, Ji-Shan Quan, Chung-Kil Song, Hua Jin, Dae-Duk Kim, Yun-Jaie Choi,

Myung-Haing Cho and Chong-Su Cho. Synergistic anti-tumor activity of paclitaxel-incorporated conjugated

linoleic acid-coupled poloxamer thermosensitive hydrogel in vitro and in vivo. Biomaterials, 2009, 30(27), 4777-4785. 
[3]    Ding-Ding Guo, Hyun-Seuk Moon, Rohidas Arote, Ji-Hye Seo, Ji-Shan Quan, Yun-Jaie Choi, Chong-Su Cho.

 Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast

cancer cells. Cancer Letters, 2007, 254(2), 244-254.
[4]    Hyun-Seuk Moon, Ding-Ding Guo, Hong-Gu Lee, Yun-Jaie Choi, Jae-Seong Kang, Kyungmin Jo, Jeong-Min

Eom, Cheol-Heui Yun and Chong-Su Cho. Alpha-eleostearic acid suppresses proliferation of MCF-7 breast

cancer cells via activation of PPARγ and inhibition of ERK 1/2. Cancer Science, 2010, 101(2), 396-402. 
[5]    Hyun-Seuk Moon, Ji-Hye Seo, Ding-Ding Guo, Hong-Gu Lee, Prati Bajracharya, Yun-Jaie Choi, Keun-Soo

Jeon , Chong-Rae Park and Chong-Su Cho. Oxidative Stabilization of Conjugated Linoleic Acid by One-pot

PEGylation. Macromolecular Research, 2011, 19(8), 822-826.
[6]    Woo Kyun Bae, Ji Hee Lee, Sang Joon Lee, Myong Suk Park, Jun Eul Hwang, Hyun Jeong Shim, Sang

Hee Cho, Ding-Ding Guo, Chong-Su Cho, In-Kyu Park and Ik Joo Chung. Enhanced Anti-Cancer Effect of

5-Fluorouracil Loaded into Thermo-Responsive Conjugated Linoleic Acid-Incorporated Poloxamer Hydrogel

on Metastatic Colon Cancer Models. Journal of Nanoscience and Nanotechnology 11, 1425-1428, 2011.
[7]    Kang Mi Lan, Hu-lin Jiang, Ding Ding Guo, Chong Soo Cho, Sang Gyun Kang, Deog Yong Lee, Nabin

Rayamahji, Yeon Soo Seo,

Han Sang Yoo. Chitosan Microspheres Containing Bordetella bronchiseptica Antigens as Novel Vaccine

Against Atrophic Rhinitis in Pigs. Journal of Microbiology and Biotechnology 2008, 18(6): 1179-1185. 
[8]    Ji-Hye Seo, Hyun-Seuk Moon, In-Yong Kim, Ding-Ding Guo, Hong-Gu Lee, Yun-Jaie Choi, Chong-Su Cho.

PEGylated conjugated linoleic acid stimulation of apoptosis via a p53-mediated signaling pathway in MCF-7

breast cancer cells. European Journal of Pharmaceutics and Biopharmaceutics, 2008, 70(2), 621-626.
[9]    Hyun-Seuk Moon, Hong-Gu Lee, Ji-Hye Seo, Ding-Ding Guo, In-Yong Kim, Chung-Soo Chung, Tae-Gyu

Kim, Yun-Jaie Choi, Chong-Su Cho. Lipolysis is stimulated by PEGylated conjugated linoleic acid through the

 cyclic adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: Activation of MEK/ERK

MAPK signaling pathway and hyper-secretion of adipo-cytokines. Journal of Cellular Physiology, 2008,

 214 (2), 283-294.
[10]    Ji-Shan Quan, Hu-Lin Jiang, Eun-Mi Kim, Hwan-Jeong Jeong, Yoon-Jaie Choi, Ding-Ding Guo, Mi-Kyong

Yoo, Hong-Gu Lee and Chong-Su Cho. pH-sensitive and mucoadhesive thiolated Eudragit-coated chitosan

microspheres. International Journal of Pharmaceutics. 2008, 359(1-2), 205-210.
[11]    Hyun-Seuk Moon, Hong-Gu Lee, Ji-Hye Seo, Ding-Ding Guo, In-Yong Kim, Chung-Soo Chung, Tae-Gyu Kim,

Yun-Jaie Choi, Chong-Su Cho. Lipolysis is stimulated by PEGylated conjugated linoleic acid through the cyclic

adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: Activation of MEK/ERK MAPK signaling

 pathway and hyper-secretion of adipo-cytokines. Journal of Cellular Physiology, 2008, 214 (2), 283-294.
[12]    Hyun-Seuk Moon, Hong-Gu Lee, Ji-Hye Seo, Chung-Soo Chung, Ding-Ding Guo, Tae-Gyu Kim, Yun-Jaie Choi,

Chong-Su Cho. Leptin-induced matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated

linoleic acid. Biochemical and Biophysical Research Communications. 2007, 356(4), 955-960.
[13]    Hyun-Seuk Moon, Ding-Ding Guo, Ho-Hyun Song, In-Yong Kim, Hu-Lin Jiang, You-Kyoung Kim, Chung-Soo

 Chung, Yun-Jaie Choi, Hong-Ku Lee and Chong-Su Cho. Regulation of adipocyte differentiation by PEGylated

all-trans retinoic acid: reduced cytotoxicity and attenuated lipid accumulation. Journal of Nutritional Biochemistry,

2007, 18(5), 322-331.
[14]    Mi Lan Kang, Hu-Lin Jiang, Sang Gyun Kang, Ding-Ding Guo. Pluronic F127 enhances the effect as an adjuvant

of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin.

Vaccine, 2007, 25 (23), 4602-4610.
[15]    Seog-Jin Seo, Hyun-Seuk Moon, Ding-Ding Guo, Sang-Heon Kim, Toshihiro Akaikec and Chong-Su Cho. Receptor

-mediated delivery of all-trans-retinoid acid (ATRA) to hepatocytes from ATRA-loaded poly(N-p-vinylbenzyl-4- o-β-d-

galactopyranosyl-d-gluconamide) nanoparticles. Materials Science and Engineering: C, 2006, 26(1), 136-141.
[16]    Chong-Su Cho, Ding-Ding Guo, Hu-Lin Jiang, You-Kyoung Kim, Yun-Jaie Choi and Myung-Haing Cho. Design

of degradable polyethylenimines as DNA and siRNA carriers in vitro and in vivo. Journal of the National Academy of

Sciences Republic of Korea, 2010, 49(1), 293-322.
[17]    Ding-Ding Guo, Rohidas Arote, Hu-Lin Jiang, Mi-Kyong Yoo, Hyun-Seuk Moon, Chong-Su Cho. Release of

All-Trans Retinoic Acid (RA) from RA-loaded Poly(ester amine) Based on Polyethylenimine and Polycaprolactone for

Intracellular Delivery. Key Engineering Materials. 2007, 342-343, 429-432. 
[18]    Ji-Hye Seo, Hyun-Seuk Moon, Ding-Ding Guo, Hong-Goo Lee, Yun-Jaie Choi, Chong-Su Cho. PEGylation of

Conjugated Linoleic Acid and Its Application as an Anti-Cancer Prodrug. Key Engineering Materials. 2007, 342-343, 441-444. 

参编书籍

Ji-Shan Quan, Hu-Lin Jiang, Jia-Hui Yu, Ding-Ding Guo, Rohidas Arote, Yun-Jaie Choi and Chong-Su Cho. Nanoparticles:

New Research. Chapter 13: Polymeric Nanoparticles for Oral Delivery of Protein Drugs. ISBN: 978-1-60456-704-5. 2008,

Nova Science Publishers, Inc.

研究与招生方向

招生方向：微生物与生化药学研究方向
研究方向：非病毒基因载体的研究；医用高分子材料；生物制药